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Transcription factor-based molecular subtyping of SCLC. (a) Study design. (b) Venn diagram showing the number of samples assessed by IHC (main study cohort), targeted exome, and WTS. (c) IHC subtypes (left) and WTS subtypes (right). (d) Differentially expressed genes among IHC subtypes (left) and among NE subset (right). (e) PCA of IHC-A, IHC-AN, and SCLC-N. (f) Representative H&E images of the five molecular subtypes.
