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. 2024 Mar 1;27(4):109400. doi: 10.1016/j.isci.2024.109400

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© 2024 The Authors

This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Effects of RhoA inhibition on the histology of intestinal epithelium and barrier function

(A and B) The number of Olfm4⁺ stem cells was determined by immunohistochemistry. Representative results are shown in (A). Scale bars: 50 μm (left) and 5 μm (right). The number of Olfm4⁺ cells located at the base of the crypt (cell positions 0–4) in RhoA^T19N (Vil-Cre⁺;RhoA^T19N) and control (Vil-Cre⁻;RhoA^T19N) mice was quantified in (B).

(C) The total number of cells (hematoxylin staining) as well as goblet (1% Alcian blue staining), enteroendocrine (Grimelius staining), and Paneth (anti-lysozyme immunostaining) cells were quantified in the villus and crypt compartments of the small intestine of RhoA^T19N and control mice. N = number of animals per group. The mean ± SEM is shown. n/s: not significant (Student’s t test p > 0.05).