Table 2.

Narrative synthesis for Glasgow Outcome Scale score

Study author	Number of patients	Comparison	Presentation of outcome	Results		Conclusions
				Intervention	Comparator
Vialet et al. [23]	N = 20	7.5% HTS bolus versus 20% mannitol bolus	Reports number of patients with severe disability or deceased at 90 days	Severe disability, n = 6 Death, n = 4	Severe disability, n = 5 Death, n = 5	All patients in both groups either developed severe disability or died by 90 days. No meaningful difference in long-term outcome between groups
Kumar et al. [21]	N = 30	3% HTS bolus versus 20% mannitol bolus	Reports number of patients surviving with or without disability and number of patients in a vegetative state or deceased by 6 months	Survival with or without disability, n = 12	Survival with or without disability, n = 13	No meaningful difference in survival with or without disability
				Vegetative state or death, n = 2	Vegetative state or death, n = 3	No meaningful difference in rate of vegetative state or death
Jagannatha et al. [20]	N = 30	3% HTS bolus versus 20% mannitol bolus	Defines “favorable outcome” as “good recovery,” “moderate disability,” or “severe disability”	Favorable outcome, n = 2	Favorable outcome, n = 0	No meaningful difference in long-term outcome between treatment groups
			Defines “unfavorable outcome” as “persistent vegetative state” or “death”	Unfavorable outcome, n = 12	Unfavorable outcome, n = 16

HTS hypertonic saline