Table 2.

Associations between tertiary lymphoid structure and clinicopathological characteristics

Parameters	Number of studies	Number of cases	OR (95%CI)	χ2 value	P value	Relationship with TLS
Age	4	1899	1.024 (0.722–1.453)	0.018	0.895	Non-significance
Gender	5	667	1.098 (0.936–1.287)	1.319	0.251	Non-significance
Tumor size	2	824	0.674 (0.505–0.901)	7.134	0.008	Negative
T stage	3	388	0.187 (0.096–0.366)	27.213	< 0.001	Negative
N stage	5	1219	0.758 (0.608–0.944)	6.127	0.013	Negative
pTNM stage	7	2744	0.921 (0.808–1.050)	1.511	0.219	Non-significance
Differentiation status	5	1538	1.038 (0.868–1.240)	0.164	0.685	Non-significance
Lauren class (Intestinal vs. Diffuse)	2	2138	1.647 (1.385–1.959)	31.977	< 0.001	Positive
Lauren class (Intestinal vs. Mix)	2	1021	2.675 (1.722–4.156)	20.343	< 0.001	Positive
Lauren class (Diffuse vs. Mix)	2	1333	1.624 (1.050–2.513)	4.818	0.028	Positive

CI confidence interval, OR odds ratio, pTNM pathological TNM, TLS tertiary lymphoid structure