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Predefined dose levels for esmolol infusion
| Dose level | Starting dosage (mcg.kg.min−1) | Increment (mcg.kg.min−1) | Estimated prior probability of dose-limiting toxicity |
|---|---|---|---|
| 1 | 5 | 2.5 | 0.01 |
| 2 | 10 | 5 | 0.04 |
| 3 | 16 | 8 | 0.07 |
| 4 | 25 | 12.5 | 0.10 |
| 5 | 35 | 17.5 | 0.15 |
| 6 | 46 | 23 | 0.20 |
| 7 | 62 | 31 | 0.25 |
