Fig. 1.

Misaligned environmental factors contribute to diseases through disturbing circadian clock. As the global industrialization and technological advances, rising rates of numerous diseases have coincided with altered lifestyles and work patterns. Nowadays, artificial lights or luminescent screens have been extensively popularized due to elevated work program, increased social pressure, and gradually personal habits with entertainment technological communication platforms. The prolonged nightshift work, jetlag, circadian sleep disorders, and long distance travel across multiple time zones are more frequent. All these factors sharply alter the daily sleep/wake cycle and slowly disturb internal circadian clock