Table 2.

Comparison of the serum biochemical parameters between different groups

	D1	D2	D3	D4	D5	p-value
Kidney weight (g)	1.19 ± 0.09	1.15 ± 0.11	1.02 ± 0.04††	1.17 ± 0.09	1.15 ± 0.09	< 0.001
Serum Cr (mg/dl)	0.57 ± 0.064	0.61 ± 0.86	1.08 ± 0.14†	0.62 ± 0.09	0.68 ± 0.14†††	< 0.001
BUN (mg/dl)	41.23 ± 1.14	45.04 ± 1.21††	68.51 ± 2.71†	43.19 ± 1.87	47.12 ± 2.08†††	< 0.001
Uric acid (mg/dl)	0.97 ± 0.12	1.02 ± 0.18	2.74 ± 0.07†	0.99 ± 0.15	1.37 ± 0.08†††	< 0.001

D1 control, D2 Single dose of DZN, D3 continuous dose of DZN, D4 single dose of DZN + NAC, D5 continuous dose of DZN + NAC

^†p < 0.001

^††p < 0.01

^†††p < 0.05 compared to control