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. 2024 Mar 22;15:2580. doi: 10.1038/s41467-024-46910-8

Fig. 2. Flexible binding of the Bre1 complex revealed by the 3DFlex analysis.

Fig. 2

a Distribution of the latent coordinates. Coordinates that correspond to the structures shown in (b–e) are indicated. Green and orange circles represent the volume series shown in Supplementary Movies 2 and 3, respectively. b–e Conformational changes represented by the first (b, c) and second (d, e) dimensions. b, d An overall view. c, e A close-up view. f Residues whose modifications or substitutions (H2BS112GlcNAc, H3K36M, H3K37ac, H3Y41ph, H3R42A, H3K56ac, and H3R42me2a) upregulate Bre1 activity. H2BK120 itself is also shown.