Table 2.
Parameters of the within-host model
| Parameters of the within-host model | |||
|---|---|---|---|
| Parameter | Unit | Description | Prior distribution |
| μ | h | mean of the normal distribution defining the initial parasite age distribution | U(0, 48) |
| σ | h | SD of the normal distribution defining the initial parasite age distribution | U(0, 80) |
| ρ | (unitless) | schizont-to-ring expansion factor | U(0, 100) |
| c1 | ng | maximum level of intraerythrocytic PvLDH | logN(-7.15, 0.65) within (0, 0.1) |
| c2 | h | parasite age where the intraerythrocytic PvLDH level reaches c1/2 | N(29.17, 8.40) within (0, 72) |
| δ | h−1 | in vivo death rate of parasites | U(0, 1) |
| r | h−1 | clearance rate of dead pRBCs from circulation | U(0, 2) |
| λ | h−1 | in vivo decay rate of PvLDH | U(0, 0.1) |
| kmax | h−1 | maximum parasite killing rate by CQ | N(0.213, 8.7 × 10−3) within (0, 1) |
| EC50 | ng/mL | CQ’s half-maximal effective concentration | N(15, 2) within (0, 50) |
| γ | (unitless) | Hill coefficient of the dose-response curve | Fixed to be 2.5 |
| aL | H | in vivo length of asexual life cycle | Fixed to be 48 |
The prior distributions are chosen for the population means of the model parameters. The lower bounds of the model parameters for those with a prior uniform distribution were selected based on biological plausibility (e.g., 0 as a lower bound). The priors for c1 and c2 are chosen to be the posterior distributions obtained from the ex vivo model fitting (see the green curves in Supplementary Fig. 1 in the Supplementary Information). The priors for kmax and EC50 were chosen based on the estimates from Abd Rahman et al.32.