Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Mar 22;14:6897. doi: 10.1038/s41598-024-55896-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Curcumin and Curcuma longa L. extract regulate ROS accumulation in acute and chronic CCl₄-models. Rats were intraperitoneally treated with CCl₄ (0.1 mL/100 g body weight) one time for 1 day or every other day for 4 weeks. Curcumin (200 mg/kg) or Curcuma longa L. extract (100, 200, and 300 mg/kg) was given once daily. (a) Lipid peroxidation activity was measured in 1 day and 4 week CCl₄-treated rats. (b) DHE staining in the liver was measured in 1 day and 4 week CCl₄-treated rats. (c) Liver tissues from 1 day and 4 week CCl₄-treated rats were stained with 4-HNE, and (d) the staining intensity of 4-HNE-positive cells was calculated. (e) Lipid peroxidation activity was measured in the ER fractions from the liver tissues of CCl₄-treated rats. The experiments were repeated three times using tissues from at least three different rats. ^#P < 0.05, ^###P < 0.001 vs. the control group; *P < 0.01, **P < 0.05 vs. the CCl₄ group (n = 10 rats per group). Cur: curcumin, CL: Curcuma longa L.