Table 4.
Diagnostic performance of MRI-PDFF and CAP of this study for the diagnosis of steatosis grade 0–1 versus 2–3 by different previously published thresholds.
| Author and year of references | Threshold (References) | Number of the reference population | Sensitivity, % | Specificity, % | PPV, % | NPV, % | AUROC (95% CI) | p Value* |
|---|---|---|---|---|---|---|---|---|
| MRI-PDFF | 0.316 | |||||||
| This study |
16.8% (this study) |
50 | 90.9 | 85.7 | 83.3 | 92.3 | 0.88 (0.79–0.97) | |
| Tang et al.28 | 17.4% | 77 | 86.4 | 85.7 | 82.6 | 88.9 | 0.86 (0.76–0.96) | |
| Tang et al.35 | 16.4% | 89 | 90.9 | 85.7 | 83.3 | 92.3 | 0.88 (0.79–0.97) | |
| Imajo et al.33 | 11.3% | 142 | 95.5 | 67.9 | 70.2 | 95.0 | 0.82 (0.72–0.92) | |
| Park et al.36 | 13.0% | 103 | 95.5 | 71.4 | 72.4 | 95.2 | 0.83 (0.74–0.93) | |
| Middleton et al.37 | 16.3% | 113 | 90.9 | 85.7 | 83.3 | 92.3 | 0.88 (0.79–0.97) | |
| Middleton et al.38 | 17.5% |
169 (children) |
86.4 | 85.7 | 82.6 | 88.9 | 0.86 (0.76–0.96) | |
| CAP in Castera et al.32 | 268 dB/m* | 2735 patients (537 with NAFLD; 19.6%) | 95.2 | 12.5 | 48.8 | 75 | 0.54 (0.46–0.62) | < 0.001 |
| CAP this study | 342 dB/m | 50 | 66.7 | 66.7 | 63.6 | 69.6 | 0.70 (0.54–0.85) |
*Statistical significance was considered when p values < 0.05.