Table 1.

Summary of the findings on the effect of immune thrombocytopenia plasma on megakaryocyte proliferation, differentiation, and maturation.

Autoantibody source		Megakaryocyte source	Findings	Reference
Mouse monoclonal antibodies anti-human-GPIbα and anti-αvβ3		Peripheral blood CD34+ cells	Inhibition of megakaryocyte colony formation.	[66]
53 ITP plasma	5 GPIIb/IIIa+, 14 GPIb/IX/V+, 19 GPIIb/IIIa+, GPIb/IX/V+, 15 negative	Venous cord blood CD34+ cells	Inhibition of megakaryocyte colony formation.	[67]
18 chronic ITP plasma vs control plasma	9 GPIIb/IIIa+, 5 GPIb/IX/V+, 3 GPIIb/IIIa+, GPIb/IX/V+,1 ND	Peripheral blood CD34+ cells	Inhibition of megakaryocyte colony formation. Decreased megakaryocyte maturation.	[68]
49 chronic ITP plasma vs control plasma	12 GPIIb/IIIa+, 9 GPIb/IX/V+, 8 GPIIb/IIIa+, GPIb/IX/V+, 20 negative	Human umbilical cord blood CD34+ cells	Normal megakaryocyte colony formation. Decreased megakaryocyte maturation.	[69]
21 recalcified chronic ITP plasma vs recalcified control plasma	4 GPIIb/IIIa+, 1 GPIb/IX/V+, 1 GPIaIIa+, 2 GPIIb/IIIa+, GPIaIIa+, 13 negative	Human umbilical cord blood CD34+ cells	Normal megakaryocyte maturation.	[70]
Monoclonal anti-αvβ3 autoantibody		Human umbilical cord blood CD34+ cells	Normal megakaryocyte maturation.	[71]

GP, glycoprotein; ITP, immune thrombocytopenia; ND, not determined.