Table 2.
Summary of the findings on the effect of immune thrombocytopenia plasma on megakaryocyte apoptosis.
| Autoantibody source | Megakaryocyte source | Findings | Reference | |
|---|---|---|---|---|
| ITP megakaryocytes | Decreased megakaryocyte apoptosis by CD8+ T cells from patients with ITP. | [77] | ||
| 49 chronic ITP plasma vs control plasma | 12 GPIIb/IIIa+, 9 GPIb/IX/V+, 8 GPIIb/IIIa+, GPIb/IX/V+, 20 negative | Human umbilical cord blood CD34+ cells | Decreased megakaryocyte apoptosis with consequent impaired megakaryocyte maturation and reduced platelet production. | [69] |
| 21 recalcified chronic ITP plasma vs recalcified control plasma | 4 GPIIb/IIIa+, 1 GPIb/IX/V+, 1 GPIaIIa+, 2 GPIIb/IIIa+, GPIaIIa+, 13 negative | Human umbilical cord blood CD34+ cells | Increased megakaryocyte apoptosis but no correlation with proplatelet count. | [70] |
| 11 ITP plasma, ITP bone marrow |
1 GPIIb/IIIa+, 1 GPIIb/IIIa+, GPIaIIa+, GPIb/IX/V+, 8 negative, 1 ND | Peripheral blood CD34+ cells | Increased megakaryocyte apoptosis. | [37] |
| Monoclonal anti-αvβ3 autoantibody | Human umbilical cord blood CD34+ cells | No effect on megakaryocyte apoptosis but decreased formations of proplatelets. | [71] | |
GP, glycoprotein; ITP, immune thrombocytopenia; ND, not determined.