REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit polyclonal anti-IRS-1	Cell Signaling Technology	#2382
Rabbit polyclonal anti-Erk1/2	Cell Signaling Technology	#9102
Rabbit polyclonal anti-pErk1/2 (Thr202/Tyr204)	Cell Signaling Technology	#9101
Rabbit polyclonal anti-eIF4e	Cell Signaling Technology	#9742
Rabbit polyclonal anti-peIF4e (Ser209)	Cell Signaling Technology	#9741
Rabbit polyclonal anti-Akt	Cell Signaling Technology	#9272
Rabbit polyclonal anti-pAkt (Ser473)	Cell Signaling Technology	#9271
Rabbit monoclonal anti-S6	Cell Signaling Technology	#2217
Rabbit polyclonal anti-pS6 (Ser235/Ser236)	Cell Signaling Technology	#2211
Rabbit monoclonal anti-Gsk3β	Cell Signaling Technology	#9315
Rabbit polyclonal anti-pGsk3β (Ser9)	Cell Signaling Technology	#9336
Rabbit polyclonal anti-Ampkα	Cell Signaling Technology	#2532
Rabbit polyclonal anti-pAmpkα (Thr172)	Cell Signaling Technology	#2531
Rabbit polyclonal anti-Foxo1	Cell Signaling Technology	#9462
Rabbit polyclonal anti-pFoxo1 (Ser256)	Cell Signaling Technology	#9461
Polyclonal anti-pIrs1 (Tyr608) mouse / (Tyr612) human	Millipore	Cat# 09-432; RRID: AB_1163457
Critical commercial assays
Insulin assay	LBIS Mouse Insulin ELISA Kit (Wako)	U-type (633-03411) for WT mice and T-type (634-01481) for ob/ob mice
Glycogen assay	Thermo Fisher Scientific	Amplex Red Glucose/Glucose Oxidase Assay Kit
Glucose assay	Roche	ACCU-CHECK Aviva Nano meter system
Deposited data
Transcriptome data	This paper	DNA DataBank of Japan Sequence Read Archive: DRA015836
Proteome data	This paper	ProteomeXchange Consortium: PXD048481
Phosphoproteome data	This paper	ProteomeXchange Consortium: PXD048480
Metabolome data	This paper	Table S5
Lipidome data	This paper	Table S6
Experimental models: Organisms/strains
Mouse: C57BL/6J	Japan SLC Inc.	C57BL/6JJmsSlc
Mouse: ob/ob	Japan SLC Inc.	C57BL/6JHamSlc-ob/ob
Software and algorithms
Source code	This paper	Zenodo: https://doi.org/10.5281/zenodo.8350756
Python version 2.7	Python Software Foundation	https://www.python.org
R version 4.0.3	R Core Team	https://www.r-project.org
MATLAB R2021a	MathWorks	https://jp.mathworks.com/products/matlab.html
VANTED V2.8.3	VANTED	https://www.cls.uni-konstanz.de/software/vanted/