. 2023 Aug 4;12(1):1–9. doi: 10.1016/j.prnil.2023.07.004

Table 4.

Pre- and post-operative prediction of biochemical recurrence in men treated with radical prostatectomy

Study	Prediction model	BCR years	Number of patients	Variables	Discrimination
Kattan et al⁴⁰	Probability nomogram development	5	983	Biopsy primary and secondary GG, CS, PSA	Internal: 74% External: 65–83%
D'Amico et al⁷²	Probability table	2	892	Biopsy GS, CS, PSA	NA
D'Amico et al⁷⁷	Probability graph	2	977	Biopsy GS, endorectal coil MRI T-stage, PSA, percent positive biopsy cores	NA
Tewari et al⁷⁸	Neural network	3.5	1400	Age, race, PSA, CS, biopsy GS	83%
D'Amico et al⁷⁹	Probability graph	4	823	Biopsy GS, CS, PSA, percent positive biopsy cores	80%
Cooperberg et al⁸⁰	Probability graph	3 and 5	1439	Age, PSA, biopsy GS, CS, percent positive biopsy	Internal: 66% External: 68–81%
Stephenson et al⁴¹	Probability nomogram development	10	1978,1545	PSA, CS, biopsy GS, year of surgery, number of positive and negative cores	76–79%
D'Amico et al⁷⁹	Probability graph	2	862	Pathologic stage, PSA, GS, surgical margin status	NA
Kattan et al⁴²	Probability nomogram development	5	996	PSA, GS, ECE, SV invasion, LN invasion, surgical margin status	Internal:89% External: 77–83%
McAleer et al⁸¹	Probability graph	7	2417	GG, CS, margin status, dichotomized PSA (cut point 10 ng/mL)	NA
Stephenson et al⁴³	Probability nomogram development	10	1881, 1782, 1357	PSA, GS, ECE, SV invasion, LN invasion, surgical margin status	78–86%
Suardi et al⁴⁴	Probability nomogram development	5, 10, 15, and 20	601, 2963, 3178	GS, pathologic stage, surgical margin status, type of surgery, adjuvant RT	Internal: 77–81% External: 77–86%

BCR, biochemical recurrence; GS, Gleason sum; CS, clinical stage; GG, Gleason grade; RP, radical prostatectomy; MRI, magnetic Resonance imaging; ECE, extracapsular extension; SV, seminal vesicle; LN, lymph node; RT, radiotherapy; NA, not available.