TABLE 3.

Cox proportional-hazards regression results for central and peripheral nervous system dysfunction

Combined cohort				Era 1 (January 1, 2000-September 14, 2004)			Era 2 (September 15, 2004-September 30, 2015)
Outcome	Hazard ratio	95% CI	p-value	Hazard ratio	95% CI	p-value	Hazard ratio	95% CI	p-value
CNS Dysfunction	1.08a	1.05, 1.11	<0.001	1.10	0.99, 1.22	0.08	1.08a	1.04, 1.11	<0.001
PNS 1: Symptoms	1.09	1.07, 1.11	<0.001	1.10	1.04, 1.17	<0.001	1.08	1.06, 1.10	<0.001
PNS 2: Symptoms + PN	-	-	-	1.23a	0.83, 1.83	0.31	1.15a	1.03, 1.28	0.01
PNS 3: Symptoms + EPT	-	-	-	1.00a	0.88, 1.14	0.97	1.12	1.06, 1.19	<0.001
PNS 4: Symptoms + PN + EPT	-	-	-	1.04a	0.61, 1.76	0.89	1.25a	1.03, 1.52	0.03

Note: In combined cohort, Cox proportional-hazards regression analysis was only conducted for CNS dysfunction outcome and PNS symptoms outcome.

Abbreviations: CNS, central nervous system; EPT, electrophysiological testing; PN, peripheral neuropathy; PNS, peripheral nervous system.

^aProportional hazards assumption failed and categorical time-varying analysis was performed (Table S8).