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. 1998 May;72(5):3812–3818. doi: 10.1128/jvi.72.5.3812-3818.1998

TABLE 2.

Priming with DC protects against peripheral infection and virus-induced immunopathology

Immunization (no. of bmDC)a Log10 PFU of Vacc-G2/ovaryb No. of mice protected against intracerebral LCMV infection/no. testedc
105 H8-bmDC <0.7 5/5
104 H8-bmDC <0.7 1/5
103 H8-bmDC 4.1 ± 3.5 0/5
None 6.5 ± 1.05 0/5
105 B6-bmDC 6.3 ± 0.7 0/3
a

C57BL/6 mice were immunized i.v. with H8-bmDC or unlabeled B6-bmDC or left untreated. 

b

Mice were challenged with 2 × 106 PFU of Vacc-G2 intraperitoneally. Five days later, vaccinia virus titers were determined on BSC40 cells (three to five mice per group) and are reported as mean ± standard deviation. Statistical analysis of the data with an unpaired t test revealed two-tailed significance at P < 0.05 among the groups. Data from one of two experiments are shown. 

c

Mice were challenged with 30 PFU of LCMV strain WE intracerebrally and observed twice daily for the occurrence of convulsive lymphocytic choriomeningitis. Statistical analysis of the data with an unpaired t test revealed two-tailed significance of P < 0.05 among the groups.