Table 5.
Pharmacokinetic parameters of HTX
| Parameter | Value |
|---|---|
| AUC0 − 48 h (ng∙h/mL) | 226.200 ± 4.742 |
| AUC0−∞ (ng∙h/mL) | 247.227 ± 5.325 |
| Tmax (h) | 0.500 ± 0.021 |
| Cmax (ng/mL) | 94.020 ± 3.214 |
| t1/2 (h) | 13.881 ± 1.231 |
| MRT0−∞ (h) | 14.795 ± 0.515 |
| CL/F (mg/kg)/(ng/mL)/h | 0.020 ± 0.002 |
| Vz/F (mg/kg)/(ng/mL) | 0.405 ± 0.014 |
| V1 (mg/kg)/(ng/mL) | 1.633 ± 0.003 |
| V2 (mg/kg)/(ng/mL) | 19.808 ± 2.031 |
| K12 (1/h) | 1.888 ± 0.013 |
| K21 (1/h) | 0.156 ± 0.002 |
Data expressed as mean ± standard deviation (n = 5). Abbreviations: AUC0 − 48: area under the curve from 0 to 48 h; AUC0−∞: area under the curve from 0 to infinity; tmax: time to reach maximum concentration; Cmax: maximum concentration; t1/2: elimination half-life; MRT0−∞: mean residence time from time zero to infinity; CL/F: apparent total clearance of the drug; Vz/F: apparent volume of distribution during terminal phase after non-intravenous administration; V1: apparent volume, central or plasma compartment in a two-compartment model; V2: apparent volume, peripheral compartment in a two-compartment model; K12: rate constant, central to peripheral compartment; K21: rate constant, peripheral to central compartment.