Table 2.

Amino acid sequence comparison between the French strains and the OIE-recommended vaccine strains

Amino acid position	PB2																	PB1
	63	65	105	251	295	377	395	398	411	660	661	667	684	686	699	731	754	94	114	119	200	203	329	377	578	584	618	621	644	715	754
A/equine/Ohio/1/2003	I	E	T	R	V	A	A	I	I	K	A	V	A	V	K	V	I	F	I	V	V	R	Q	D	K	R	E	K	V	V	R
A/equine/South Africa/4/2003	–	–	–	–	–	T	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–
A/equine/Ohio/113461-1/2005	–	–	–	–	–	–	–	V	V	R	–	–	–	–	–	I	–	L	–	–	–	–	–	–	I	–	–	R	–	–	–
A/equine/Richmond/2007	–	–	A	K	–	–	–	V	–	–	–	–	–	–	–	–	–	L	–	M	–	–	R	E	–	–	D	–	–	–	–
A/equine/Beuvron-en-Auge/2/2009	V	–	–	–	I	–	V	V	–	–	–	I	–	I	–	–	–	L	–	–	–	K	–	–	–	Q	–	R	–	–	–
A/equine/Paris/1/2018	V	K	–	–	–	–	–	V	–	–	T	I	T	I	R	–	V	L	V	–	I	–	–	–	–	Q	–	R	I	A	G

	PA																			NP
Amino acid position	59	64	86	98	210	237	259	321	335	348	354	367	409	465	476	505	538	626	636	136	214	257	359	430	450
A/equine/Ohio/1/2003	E	E	M	T	T	E	P	S	L	L	T	K	S	I	A	V	E	K	V	M	R	I	T	T	N
A/equine/South Africa/4/2003	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	I	–	–	–	–	K	–	–	–	–
A/equine/Ohio/113461–1/2005	–	–	–	–	–	–	–	–	–	–	–	–	–	V	–	–	–	–	–	–	–	–	–	–	–
A/equine/Richmond/2007	–	D	I	–	M	K	–	N	–	–	I	–	–	–	T	I	–	R	–	I	–	T	A	–	S
A/equine/Beuvron-en-Auge/2/2009	–	–	–	A	–	–	S	–	–	I	I	–	N	V	–	–	K	–	I	–	–	–	–	–	–
A/equine/Paris/1/2018	K	–	–	–	–	K	S	–	I	I	I	R	N	–	–	–	–	–	–	–	–	–	–	I	–

	M1						M2					NS1										NEP
Amino acid position	15	80	95	208	214	248	19	59	85	87	89	22	48	66	84	129	156	207	209	210	212	52
A/equine/Ohio/1/2003	V	V	R	R	Q	M	C	L	D	E	G	F	S	E	V	I	V	H	N	G	P	M
A/equine/South Africa/4/2003	–	–	–	–	–	–	–	–	–	D	–	V	–	–	–	T	I	–	–	–	–	–
A/equine/Ohio/113461-1/2005	–	–	–	–	–	–	–	M	–	D	–	–	–	–	–	–	–	–	–	–	–	–
A/equine/Richmond/2007	I	I	K	K	E	–	–	–	S	D	S	–	I	–	I	–	–	Y	–	–	–	–
A/equine/Beuvron-en-Auge/2/2009	–	–	–	–	–	–	–	M	G	D	–	–	–	K	–	–	–	–	–	W	–	I
A/equine/Paris/1/2018	I	–	–	–	–	I	Y	M	–	D	–	–	–	K	–	–	–	N	I	–	S	L

Amino acid identity to A/equine/Ohio/1/2003 is represented as a dot.