Table 2. Univariate and multivariate analyses of LNM in patients with gastric cancer.
| Variable | LN- | LN+ | P-value | |
|---|---|---|---|---|
| Univariate | Multivariate | |||
| Count | 48 | 80 | ||
| Radiomics score | −0.2 ± 1.5 | 1.0 ± 0.9 | <0.001 | |
| Radiomics evaluation | <0.001* | 0.001a | ||
| High risk | 34 (70.8%) | 22 (27.5%) | ||
| Low risk | 14 (29.2%) | 58 (72.5%) | ||
| BMI, kg/m2 | 23.2 ± 3.0 | 22.2 ± 2.8 | 0.085 | |
| Age, y | 0.138 | |||
| <70 | 35 (72.9%) | 48 (60.0%) | ||
| ≥70 | 13 (27.1%) | 32 (40.0%) | ||
| Sex | 0.498 | |||
| Female | 14 (29.2%) | 19 (23.8%) | ||
| Male | 34 (70.8%) | 61 (76.2%) | ||
| Diabetes | 1 (2.1%) | 16 (20.0%) | 0.004* | 0.069a |
| Hypertension | 13 (27.1%) | 27 (33.8%) | 0.431 | |
| Charlson Comorbidity Index | 0.63 | |||
| 0 | 24 (50.0%) | 34 (42.5%) | ||
| 1–2 | 21 (43.8%) | 42 (52.5%) | ||
| 3–6 | 3 (6.2%) | 4 (5.0%) | ||
| NRS-2002 | 0.026* | 0.049a | ||
| 1–2 | 35 (72.9%) | 40 (50.0%) | ||
| 3–4 | 12 (25.0%) | 32 (40.0%) | ||
| 5–6 | 1 (2.1%) | 8 (10.0%) | ||
| Hemoglobin | 0.005* | |||
| ≥100 g/L | 43 (89.6%) | 54 (67.5%) | ||
| <100 g/L | 5 (10.4%) | 26 (32.5%) | ||
| Preoperative albumin | 0.067 | |||
| ≥35 g/L | 38 (79.2%) | 51 (63.7%) | ||
| <35 g/L | 10 (20.8%) | 29 (36.2%) | ||
| PLR | 0.023* | |||
| <124.9 | 22 (45.8%) | 21 (26.2%) | ||
| ≥124.9 | 26 (54.2%) | 59 (73.8%) | ||
| NLR | 0.026* | |||
| <2.63 | 39 (81.2%) | 50 (62.5%) | ||
| ≥2.63 | 9 (18.8%) | 30 (37.5%) | ||
| CT-reported LN status | <0.001* | 0.009a | ||
| Negative | 39 (81.2%) | 39 (48.8%) | ||
| Positive | 9 (18.8%) | 41 (51.2%) | ||
| Tumor size | 0.002* | |||
| <3 cm | 25 (52.1%) | 20 (25.0%) | ||
| ≥3 cm | 23 (47.9%) | 60 (75.0%) | ||
| Tumor location | 0.277 | |||
| Cardia | 6 (12.5%) | 12 (15.0%) | ||
| Body | 15 (31.2%) | 15 (18.8%) | ||
| Antrum | 27 (56.2%) | 53 (66.2%) | ||
| Differentiation | 0.248 | |||
| Well differentiated | 31 (64.6%) | 62 (77.5%) | ||
| Poorly differentiated | 8 (16.7%) | 10 (12.5%) | ||
| Signet-ring cell | 9 (18.8%) | 8 (10.0%) | ||
| Pathological type | 0.199 | |||
| Non-ulcer type | 7 (14.6%) | 6 (7.5%) | ||
| Ulcerative type | 41 (85.4%) | 74 (92.5%) | ||
Notes.
Data shown in the table: mean ± standard deviation; N (%); Wilcoxon rank sum test and chi-squared test for univariate analysis.
P < 0.05 was statistically significant and included in multivariate logistic regression (forward: wald).
Variables finally in the model (radiomics evaluation, NRS-2002, CT-reported LN status, and diabetes).
- BMI
- body mass index
- CT
- computed tomography
- LN
- lymph node
- LNM
- lymph node metastasis
- NLR
- neutrophil-lymphocyte ratio
- NRS-2002
- Nutrition Risk Screening 2002
- PLR
- platelet-lymphocyte ratio