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. 2024 Mar 20;12:e17111. doi: 10.7717/peerj.17111

Table 2. Univariate and multivariate analyses of LNM in patients with gastric cancer.

Variable LN- LN+ P-value
Univariate Multivariate
Count 48 80
Radiomics score −0.2 ± 1.5 1.0 ± 0.9 <0.001
Radiomics evaluation <0.001* 0.001a
High risk 34 (70.8%) 22 (27.5%)
Low risk 14 (29.2%) 58 (72.5%)
BMI, kg/m2 23.2 ± 3.0 22.2 ± 2.8 0.085
Age, y 0.138
<70 35 (72.9%) 48 (60.0%)
≥70 13 (27.1%) 32 (40.0%)
Sex 0.498
Female 14 (29.2%) 19 (23.8%)
Male 34 (70.8%) 61 (76.2%)
Diabetes 1 (2.1%) 16 (20.0%) 0.004* 0.069a
Hypertension 13 (27.1%) 27 (33.8%) 0.431
Charlson Comorbidity Index 0.63
0 24 (50.0%) 34 (42.5%)
1–2 21 (43.8%) 42 (52.5%)
3–6 3 (6.2%) 4 (5.0%)
NRS-2002 0.026* 0.049a
1–2 35 (72.9%) 40 (50.0%)
3–4 12 (25.0%) 32 (40.0%)
5–6 1 (2.1%) 8 (10.0%)
Hemoglobin 0.005*
≥100 g/L 43 (89.6%) 54 (67.5%)
<100 g/L 5 (10.4%) 26 (32.5%)
Preoperative albumin 0.067
≥35 g/L 38 (79.2%) 51 (63.7%)
<35 g/L 10 (20.8%) 29 (36.2%)
PLR 0.023*
<124.9 22 (45.8%) 21 (26.2%)
≥124.9 26 (54.2%) 59 (73.8%)
NLR 0.026*
<2.63 39 (81.2%) 50 (62.5%)
≥2.63 9 (18.8%) 30 (37.5%)
CT-reported LN status <0.001* 0.009a
Negative 39 (81.2%) 39 (48.8%)
Positive 9 (18.8%) 41 (51.2%)
Tumor size 0.002*
<3 cm 25 (52.1%) 20 (25.0%)
≥3 cm 23 (47.9%) 60 (75.0%)
Tumor location 0.277
Cardia 6 (12.5%) 12 (15.0%)
Body 15 (31.2%) 15 (18.8%)
Antrum 27 (56.2%) 53 (66.2%)
Differentiation 0.248
Well differentiated 31 (64.6%) 62 (77.5%)
Poorly differentiated 8 (16.7%) 10 (12.5%)
Signet-ring cell 9 (18.8%) 8 (10.0%)
Pathological type 0.199
Non-ulcer type 7 (14.6%) 6 (7.5%)
Ulcerative type 41 (85.4%) 74 (92.5%)

Notes.

Data shown in the table: mean ± standard deviation; N (%); Wilcoxon rank sum test and chi-squared test for univariate analysis.

*

P < 0.05 was statistically significant and included in multivariate logistic regression (forward: wald).

a

Variables finally in the model (radiomics evaluation, NRS-2002, CT-reported LN status, and diabetes).

BMI
body mass index
CT
computed tomography
LN
lymph node
LNM
lymph node metastasis
NLR
neutrophil-lymphocyte ratio
NRS-2002
Nutrition Risk Screening 2002
PLR
platelet-lymphocyte ratio