Therapeutic effects of IMQ@IONs/ICG on Panc02-H7 orthotopic PC. (A) Photographs of the primary tumors 7 days after different treatments. Scale bar = 2 cm. (B) Representative photographs of mesentery metastases 7 days after IMQ@IONs/ICG + L treatments. (C) Numbers of mesentery metastases 7 days after different treatments. (* p < 0.05, vs PBS group, n = 3, one-way analysis of variance (ANOVA) with Tukey test) (D) Survival rates of Panc02-H7 orthotopic tumor-bearing mice after various treatments. (*** p < 0.001, vs PBS group, #p < 0.05, vs IONs/ICG + L, n = 8, two-tailed Mantel–Cox test). (E) Average body weight variation of Panc02-H7 orthotopic tumor-bearing mice after various treatments (n = 8). Data are expressed as mean ± SD.