Table 2. Types and characteristics of TadA variants in ABEs.

Deaminase name	BE name	Engineering sties	Features	Reference
TadA-7.10	ABE7.10	W23R; H36L, P48A, R51L, L84F, A106V, D108N, H123Y, S146C, D147Y, R152P, E155V, I156F, K157N	Exhibited efficient A-to-G editing within its editing window (A4–A7) in mammalian cells	Gaudelli et al. 2017
TadA-7.10- F148A, V106W	ABE7.10- F148A, V106W	TadA-7.10 + F148A, V106W	Reduce the RNA off-targeting of ABEs	Zhou et al. 2019
TadA-minABEmax	miniABEmax	TadA-7.10 + K20A/R21A, V82G	Reduce the RNA off-targeting of ABEs	Grunewald et al. 2019b
TadA-8e	ABE8e	TadA-7.10 + A109S, T111R, D119N, H122N, S146C, F149Y, T166I, D167N	Deaminate DNA at higher rate than ABE7.10	Lapinaite et al. 2020, Richter et al. 2020
TadA-9	ABE9	TadA-8e + L145T	ABE9 has a narrower editing window compare to ABE7.10 and ABE8e	Chen et al. 2023