Table 3. Types and characteristics of ADAR deaminases used in RNA editing.

Deaminase name	BE name	Engineering sties	Features	Reference
ADAR2 DD	REPAIR	E488Q	Enable A-to-I RNA editing at the transcriptome level	Cox et al. 2017
ADAR2DD	REPAIRv2	E488Q, T375G	Induce specific and efficient A-to-I base editing in RNA	Cox et al. 2017
ADAR2DD	RESCUEr3	E488Q, V351G, S486A, T375S	Improve C-to-U deamination activity	Abudayyeh et al. 2019
ADAR2DD	RESCUE	E488Q, V351G, S486A, T375S, S370C, P462A, N597I, L332I, I398V, K350I, M383L, D619G, S582T, V440I, S495N, K418E, S661T	Significantly increased C-to-U deamination activity at all tested targets in the context of any flanking 5' and 3' bases while retaining A-to-I editing activity.	Abudayyeh et al. 2019