Fig. 2.

a) Venn diagrams show the number of proteins that have been positively identified in the non-calcified and calcified areas within each AV, middle intersections show the number of proteins that are common to both groups. b) Venn diagram of the proteins common to calcified and non-calcified areas of the 5 valves. Overlaps show the number of these proteins common between valves (5/5: 142 proteins, 4/5: 49, 3/5: 57). c) The 10 pathways found to be most modified between calcified and non-calcified areas according to Ingenuity Pathways Analysis for the 248 proteins found in at least 3 of 5 valves. Blue bars indicate negative activation while orange bars are positive; the color intensity increases with higher absolute activation z-score values.