Table 2.
Hazard Ratios for Mortality Outcomes by the Quartiles of LDL Cholesterol
| LDL Cholesterol Categories by Quartiles | All Cause | CVD | Cancer | Non-CVD/Noncancer |
|---|---|---|---|---|
| Fully Adjusted HR (95% CI) | ||||
| Total | ||||
| 1st quartile (0.5–2.8 mmol/L) | 1.33 (1.13–1.56) | 1 (Ref) | 1.56 (1.22–2.01) | 1.51 (1.13–2.00) |
| 2nd quartile (2.9–3.3 mmol/L) | 1.17 (0.99–1.39) | 1.03 (0.75–1.41) | 1.29 (0.99–1.68) | 1.29 (0.96–1.75) |
| 3rd quartile (3.4–3.8 mmol/L) | 1 (Ref) | 1.16 (0.84–1.60) | 1 (Ref) | 1 (Ref) |
| 4th quartile (3.9–9.9 mmol/L) | 1.16 (0.97–1.38) | 1.32 (0.95–1.82) | 1.19 (0.91–1.57) | 1.13 (0.81–1.56) |
| Males | ||||
| 1st quartile (0.5–2.7 mmol/L) | 1.58 (1.27–1.98) | 1.04 (0.68–1.60) | 1.66 (1.18–2.32) | 2.18 (1.44–3.31) |
| 2nd quartile (2.8–3.2 mmol/L) | 1.36 (1.08–1.71) | 1 (Ref) | 1.42 (1.00–2.01) | 1.78 (1.16–2.74) |
| 3rd quartile (3.3–3.7 mmol/L) | 1 (Ref) | 1.08 (0.69–1.69) | 1 (Ref) | 1 (Ref) |
| 4th quartile (3.8–9.9 mmol/L) | 1.23 (0.97–1.57) | 1.22 (0.78–1.90) | 1.30 (0.91–1.87) | 1.22 (0.76–1.96) |
| Females | ||||
| 1st quartile (0.6–2.8 mmol/L) | 1.08 (0.86–1.36) | 1 (Ref) | 1 (Ref) | 1.15 (0.78–1.71) |
| 2nd quartile (2.9–3.4 mmol/L) | 1 (Ref) | 1.20 (0.74–1.93) | 0.84 (0.60–1.18) | 1 (Ref) |
| 3rd quartile (3.5–3.9 mmol/L) | 1.02 (0.80–1.29) | 1.29 (0.79–2.13) | 0.77 (0.53–1.11) | 1.11 (0.73–1.70) |
| 4th quartile (4.0–7.0 mmol/L) | 1.03 (0.81–1.32) | 1.60 (0.98–2.64) | 0.67 (0.45–1.00) | 1.15 (0.74–1.79) |
Notes: Adjustment was made on all variables listed in Table 1. To convert LDL cholesterol in mmol/L to mg/dL, multiply by 38.67. CI = confidence interval; CVD = cardiovascular disease; HR = hazard ratio; LDL = low-density lipoprotein.