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. 2013 Dec 13;2013(12):CD004975. doi: 10.1002/14651858.CD004975.pub3

Comparison 2. Analysis for amoxicillin treatment trials only.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Clinical cure rate at the end of therapy 2 177 Risk Ratio (M‐H, Random, 95% CI) 1.05 [0.82, 1.34]
2 Clinical cure rate during therapy 1 63 Risk Ratio (M‐H, Fixed, 95% CI) 1.17 [1.01, 1.37]
3 Clinical cure rate at post‐treatment 1 95 Risk Ratio (M‐H, Fixed, 95% CI) 0.93 [0.85, 1.03]
4 AOM complications: Recurrent AOM after completion of therapy 1 100 Risk Ratio (M‐H, Random, 95% CI) 4.16 [0.48, 35.95]
5 Specific adverse reactions to medication: Diarrhoea 1 110 Risk Ratio (M‐H, Fixed, 95% CI) 1.0 [0.06, 15.59]
6 Specific adverse reactions to medication: Skin adverse events 1 110 Risk Ratio (M‐H, Fixed, 95% CI) 1.0 [0.21, 4.74]
7 Compliance rate 1 67 Risk Ratio (M‐H, Random, 95% CI) 1.0 [0.94, 1.06]