Comparison 3. Analysis for amoxicillin/clavulanate treatment trials only.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Clinical cure rate at the end of therapy	3	1424	Risk Ratio (M‐H, Fixed, 95% CI)	1.03 [0.99, 1.07]
2 Clinical cure rate during therapy	1	385	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.70, 1.42]
3 Clinical cure rate at post‐treatment	3	1381	Risk Ratio (M‐H, Fixed, 95% CI)	1.04 [0.98, 1.10]
4 AOM complications: Recurrent AOM after completion of therapy	2	929	Risk Ratio (M‐H, Random, 95% CI)	1.01 [0.39, 2.60]
5 Adverse reactions to medication: Overall	2	878	Risk Ratio (M‐H, Random, 95% CI)	0.92 [0.52, 1.63]
6 Specific adverse reactions of medication: Diarrhoea	3	1453	Risk Ratio (M‐H, Fixed, 95% CI)	0.70 [0.48, 1.00]
7 Specific adverse reactions to medication: Skin adverse events	2	990	Risk Ratio (M‐H, Fixed, 95% CI)	0.72 [0.44, 1.17]
8 Compliance rate	3	1453	Risk Ratio (M‐H, Random, 95% CI)	1.05 [0.98, 1.13]