Table 2.
Hazard ratios (HRs) and 95% Confidence Intervals (95%CI) for liver cancer by blood DNA methylation markers in the Strong Heart Study
| CpG site | Model 1 | Model 2 | Associated genes | Gene functions | ||
|---|---|---|---|---|---|---|
| HR (95% CI) | p-value* | HR (95% CI) | p-value | |||
| cg16057201 | 1.25 (1.15, 1.36) | 7.01E−08 | 1.25 (1.14, 1.37) | 1.94E−06 | MRFAP1 | Cell growth |
| cg26804244 | 0.68 (0.58, 0.80) | 3.69E−06 | 0.70 (0.59, 0.82) | 2.57E−05 | ||
| cg08550308 | 0.77 (0.68, 0.87) | 1.90E−05 | 0.77 (0.67, 0.88) | 1.01E−04 | ||
| cg06778410 | 0.62 (0.47, 0.81) | 6.08E−04 | 0.62 (0.47, 0.83) | 1.04E−03 | ||
| cg17739868 | 0.74 (0.67, 0.82) | 2.87E−08 | 0.75 (0.67, 0.84) | 8.17E−07 | ||
| cg03928653 | 0.73 (0.63, 0.84) | 1.91E−05 | 0.75 (0.65, 0.87) | 8.75E−05 | ||
| cg18854531 | 0.71 (0.60, 0.83) | 4.36E−05 | 0.71 (0.60, 0.85) | 1.28E−04 | ||
| cg17519011 | 0.71 (0.58, 0.87) | 1.11E−03 | 0.70 (0.56, 0.86) | 8.06E−04 | A4GALT | Globoside synthesis |
| cg04967787 | 0.53 (0.41, 0.70) | 4.62E−06 | 0.58 (0.44, 0.75) | 4.79E−05 | PPRC1 | Mitochondrial biogenesis |
The HR is reported per SD of Beta for differential methylation markers
Model 1: age, sex, center, and immune cell proportions
Model 2: Model 1 + alcohol (never, ever, current), smoking (never, ever, current), BMI and LDL-cholesterol