Table 6.
Nested case-control analysis for thromboembolic events with onset after week 12: change from baseline to last known laboratory parameters
| Category | Cases n (%) |
Controls n (%) |
Odds ratio (95% CI) | P value |
|---|---|---|---|---|
| Change from baseline to last known Hb level before the event onset (g/dL) | ||||
| < − 0.5 | 107 (21.6) | 201 (13.6) | 1.75 (1.34–2.30) | < 0.001 |
| − 0.5 to < 0.0 | 52 (10.5) | 159 (10.8) | 1.08 (0.77–1.51) | 0.655 |
| ≥ 0.0 | 336 (67.9) | 1113 (75.6) | Ref | |
| Change from baseline to last known ferritin level before the event onset (ng/mL) | ||||
| < − 250 | 205 (41.4) | 559 (38.0) | 1.34 (1.00–1.80) | 0.050 |
| − 250 to < 0 | 206 (41.6) | 603 (41.0) | 1.26 (0.94–1.68) | 0.123 |
| ≥ 0 | 84 (17.0) | 308 (21.0) | Ref | |
| Change from baseline to last known TSAT before the event onset (%) | ||||
| < − 15 | 123 (24.9) | 299 (20.4) | 1.36 (1.03–1.79) | 0.031 |
| − 15 to < 0 | 194 (39.3) | 598 (40.8) | 1.04 (0.82–1.31) | 0.734 |
| ≥ 0 | 177 (35.8) | 569 (38.8) | Ref | |
| Change from baseline to last known platelet count before the event onset (104/µL) | ||||
| < 0 | 250 (50.7) | 782 (53.3) | Ref | |
| 0 to < 3 | 124 (25.2) | 404 (27.6) | 0.96 (0.75–1.23) | 0.750 |
| ≥ 3 | 119 (24.1) | 280 (19.1) | 1.34 (1.03–1.73) | 0.028 |
| Change from baseline to last known hsCRP level before the event onset (mg/dL) | ||||
| < 0.0 | 184 (46.5) | 544 (46.1) | Ref | |
| 0.0 to < 0.5 | 117 (29.5) | 408 (34.6) | 0.90 (0.68–1.19) | 0.464 |
| ≥ 0.5 | 95 (24.0) | 227 (19.3) | 1.28 (0.95–1.73) | 0.105 |
| Change from baseline to last known MCV before the event onset (fL) | ||||
| < − 2 | 97 (34.2) | 236 (29.1) | 1.23 (0.87–1.74) | 0.235 |
| − 2 to < 0 | 43 (15.1) | 126 (15.5) | 1.17 (0.75–1.82) | 0.500 |
| ≥ 0 | 144 (50.7) | 450 (55.4) | Ref | |
CI confidence interval, Hb hemoglobin, hsCRP high-sensitivity C-reactive protein, MCV mean corpuscular volume, ref reference, TSAT transferrin saturation