Fig. 2. P-tau212 immunohistochemical staining on Alzheimer’s Disease cases.

Hippocampal sections were stained with the ptau212 antibody recognizing the phosphorylated residues at 212. In both cases 2 and 5, strong tau staining was observed (a, e). In the entorhinal cortex neuropil threads were seen covering the parenchyma, along with neurofibrillary tangles (b and f arrows) and dystrophic neurites observed in concentrated areas (b and f asterisks). Higher magnification images of the CA1 subfield of the hippocampus and the granule cell layer (GCL) show the intensity of the staining in the neurofibrillary tangles (CA1: c and g, GCL: d and h). Scale bar represents 500 µm in a and e; 50 µm in b and f; 25 µm in c, d, g, and h.