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. 2024 Mar 23;15:2615. doi: 10.1038/s41467-024-46876-7

Fig. 3. Representative neurofibrillary tangles in autopsy-diagnosed AD brain tissue are phosphorylated jointly at p-tau212 and p-tau217.

Fig. 3

The figure shows confocal microscopy images of immunofluorescent staining of selected tangles from temporal cortex tissue sections of three independent autopsy-verified AD patients. The individual was neuropathologically evaluated to be at Braak VI at autopsy, and they had been given an AD diagnosis for 15 years prior to death. Each micrograph shows co-staining with the nuclear stain DAPI in cyan hot, p-tau212 in magenta and p-tau217 (A, b) (or AT8 [p-tau202/205] in (B) in orange hot. The merged images show colocalization of the different color channels. The scale bar is 20 µm in each image.