Table 1.
Demographic characteristics of the Slovenia memory clinic cohort
| SCD | Non-AD MCI | AD-MCI | AD-Dementia | |
|---|---|---|---|---|
| Sample size | 24 | 22 | 41 | 62 |
| Age, y | 64.30 ± 8.51c,d | 67.67 ± 13.07c,d | 75.46 ± 5.71a,b | 75.22 ± 7.46a,b |
| Sex, F, n (%) | 13/24 (54.2%) | 12/22 (54.6%) | 26/41 (63.4%) | 39/62 (62.9%) |
| MMSE | 28 (26.25–29) | 25 (24.8–26) | 27 (25–29) | 21 (17–25)a,c |
| CSF Aβ42, pg/ml | 1270 (1120–1465)c,d | 1341 (1082–1489)c,d | 696 (606.5–949.5)a,b | 623.5 (550–751.8)a,b |
| CSF Aβ42/Aβ40 ratio | 1.30 (0.11–0.14)c,d | 0.115 (0.11–0.13)c,d | 0.061 (0.49–0.07)a,b | 0.048 (0.038–0.058)a,b |
| CSF total-tau, pg/ml | 200 (181.0–291)c,d | 231 (198.3–304.8)c,d | 391 (333–584.5)a,b,d | 815 (645–1090)a,b,c |
| CSF p-tau181 (Innotest), pg/ml | 38 (33.5–48)c,d | 43.5 (37.5–50.3)c,d | 64 (55–101.5)a,b,d | 111 (92.3–140.5)a,b,c |
| Plasma p-tau212, pg/ml | 1.750 (0.9–2.8)c,d | 1.850 (1.3–3.6)c,d | 3.4 (2–5)a,b,d | 5.9 (4–7.8)a,b,c |
| Plasma p-tau217, pg/ml | 1.7 (0.8–3)c,d | 2.1 (1.4–3.8)c,d | 5.1 (3.3–7.8)a,b,d | 8.1 (5.9–10.6)a,b,c |
aStatistically different from SCD.
bStatistically different from non-AD MCI.
cStatistically different from AD-MCI.
dStatistically different from AD-Dementia.