Fig. 1. To predict the ability of nucleoside derivatives to form hydrogels based on machine learning.

An optimal model was constructed for nucleoside derivatives hydrogel-forming ability prediction, and potential gelators were selected based on the optimal model external application and the hydrogel-forming ability were experimentally verified. Besides, the self-assembly mechanism of the cation-independent hydrogel was explored, which could be applied in rapid visual detection of Ag⁺ and cysteine.