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. 2024 Mar 23;8:74. doi: 10.1038/s41698-024-00574-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a The IFNα concentration in the cell supernatant from A549 and H1299 cells with the indicated shRNAs. b The IFNα concentration in the cell supernatant from A549 and H1299 cells with the indicated lentiviral vectors. c Exosome secretion inhibitor DMA treatment significantly reduced the IFNα concentration in the cell supernatant of Rab27A-overexpressing A549 and H1299 cells. d The upregulation effect of TYK2 phosphorylation mediated by Rab27A-overexpression could be reversed by DMA in A549 and H1299 cells. e IFNA2-knockdown reversed the upregulation effect of IFNα concentration in the cell supernatant mediated by Rab27A-overexpression in A549 and H1299 cells. f The upregulation effect of TYK2 phosphorylation mediated by Rab27A-overexpression could be reversed by IFNA2-knockdown in A549 and H1299 cells.