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. 2024 Mar 23;8:74. doi: 10.1038/s41698-024-00574-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a The viability of A549 and H1299 cells was determined by CCK-8 assay after the cells treated with Cerdulatinib at the indicated concentration. The IC₅₀ of Cerdulatinib for each cell line was calculated according to the cell viability value. b Cell lysates from A549 and H1299 cells treated with the indicated Cerdulatinib concentration were subjected to Western blot analysis to detect the phosphorylation activation of TYK2 (Y1054). c Cerdulatinib treatment (1 μM) reversed the promoting effect on cell growth ability induced by Rab27A-overexpression in A549 and H1299 cells. d Cerdulatinib treatment (1 μM) reversed the promoting effect on clonogenic ability induced by Rab27A-overexpression in A549 and H1299 cells (scale bar, 1 cm). e Cell lysates were subjected to Western blot analysis to detect the PCNA protein level. f Cerdulatinib treatment (1 μM) reversed the promoting effect on cell migration and invasion ability induced by Rab27A-overexpression in A549 and H1299 cells (Scale bar, 200 μm).