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. 2024 Mar 23;14:6958. doi: 10.1038/s41598-024-57286-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of AAV2- and LV-mediated MYOC editing on ER stress markers in TM cells. (A) Representative Western blot showing decreased protein levels of MYOC, GRP78, GRP94, and CHOP predominantly in LV_crMYOC treated cells compared to AAV2_crMYOC (n = 3). (B) The densitometric analysis confirms significant decrease in MYOC and associated ER stress markers with LV_crMYOC treatment only, with no significant effect observed in AAV2_crMYOC treated cells. Unpaired (two-tailed) student t test, with *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001. Quantitative data represented as mean ± SEM.