The Pruritus Numeric Rating Scale (Pruritus NRS) is a novel scale for assessing the severity of itch in atopic dermatitis (AD).

A mixed-methods approach was used to explore the content validity and psychometric properties of the Pruritus NRS.

Qualitative results supported itch as a key symptom of AD, and indicated that the Pruritus NRS was relevant, appropriate, and interpreted as intended.

Quantitative results showed the Pruritus NRS is valid, reliable, and able to detect change in the context of a clinical trial in AD.

The Pruritus NRS was found to be fit-for-purpose for use in clinical trials of AD treatments among patients with moderate-to-severe disease.