. 2024 Mar 23;25:139. doi: 10.1186/s12931-024-02764-8

Table 4.

Asthma status classifications in relation to DEHP exposures

Urinary metabolites		Severe/very severe vs. control (n = 36/33)		Mild/moderate vs. control (n = 44/33)		Atopic asthma vs. control (n = 66/131)		Non-atopic asthma vs. control (n = 14/131)
Urinary metabolites		ORs	P-value^a	ORs	P-value^a	ORs	P-value^b	ORs	P-value^b
Model1	MEHP	1.38	0.07	1.33	0.10	1.56	< 0.001*	1.61	0.002*
Model2	MEHHP	3.85	< 0.001*	3.60	< 0.001*	2.81	< 0.001*	3.19	< 0.001*
	MEHHP/MEHP	1.07	0.22	1.05	0.34	1.02	0.60	1.06	0.11
Model3	MEHP + MEHHP	3.19	< 0.001*	2.98	< 0.001*	2.69	< 0.001*	3.04	< 0.001*
Urinary metabolites		Asthma/T2DM vs. control (5/33)		Asthma without T2DMvs control (n = 75/33)		Asthma/HPTS vs. control (n = 14/29)		Asthma without HPTS vs. control (n = 66/29)
Urinary metabolites		ORs	P-value^c	ORs	P-value^c	ORs	P-value^c	ORs	P-value^c
Model1	MEHP	1.18	0.51	1.41	0.06	1.11	0.63	1.43	0.07
Model2	MEHHP	4.40	< 0.001*	4.45	< 0.001*	4.50	0.001*	5.85	< 0.001*
	MEHHP/MEHP	1.10	0.16	1.06	0.27	1.14	0.04	1.06	0.33
Model3	MEHP + MEHHP	3.18	0.003*	3.51	< 0.001*	3.02	0.004*	3.95	< 0.001*
Urinary metabolites		Asthma/T2DM/HPTS vs. control (n = 1/29)		Asthma without T2DM & HPTS vs. control (n = 62/29)		Asthma/allergic rhinitis vs. control (n = 52/27)		Asthma without allergic rhinitis vs. control (n = 28/27)
Urinary metabolites		ORs	P-value^c	ORs	P-value^c	ORs	P-value^c	ORs	P-value^c
Model1	MEHP	0.70	0.41	1.39	0.15	2.01	0.03	1.62	0.06
Model2	MEHHP	5.36	0.01*	7.02	< 0.001*	19.98	< 0.001*	10.62	< 0.001*
	MEHHP/MEHP	1.25	0.02	1.09	0.23	1.04	0.65	1.08	0.24
Model3	MEHP + MEHHP	2.85	0.07	4.20	< 0.001*	10.47	< 0.001*	6.45	< 0.001*

T2DM, Type 2 Diabetes Mellitus

HPTS, hypertension

^a Multinomial logistic regression, adjusted for age, atopy, education, and household income

^b Multinomial logistic regression, adjusted for age, BMI, education, and household income

^c Multinomial logistic regression, adjusted for age, BMI, atopy, education, and household income

*To minimize the risk of type I errors in our multiple comparison study, we set the α level to 0.01666667 (0.05/3) using the Bonferroni correction method