Table 5.

Correlation between urinary MEHP + MEHHP and a panel of inflammatory markers

Urinary DEHP metabolite	Stratification	Status	MEHP + MEHHP	MEHP	MEHHP	HEL	4-HNE	S1P	C1P	IL-1β	IL-6	IL-8	IL-10	IL-13	IL-17	IFN-γ	MCP-1	MIP-1β
			ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ
MEHP + MEHHP	Asthma	+	NA	0.84***	0.92***	0.19*				-0.24**	-0.31***	-0.22**		-0.20**	-0.22**	-0.21**	-0.18*	-0.22**
		-	NA	0.81***	0.94***	0.17**	0.27***
	Asthma-phenotypic clusters	A	NA	0.75***	0.84***						-0.61**							-0.54**
		B	NA	0.78***	0.94***					-0.32*	-0.32*	-0.30*	-0.35*	-0.32*	-0.29*
		C	NA	0.93***	0.95***
		D	NA	0.78***	0.84***								0.39*
		E	NA
		F	NA	0.87***	0.97***
	Asthma severitya	++	NA	0.88***	0.92***									-0.27*
		+	NA	0.81***	0.92***			-0.26*		-0.40***	-0.50***	-0.35***			-0.37***	-0.38***	-0.30**	-0.38***
	Atopic	+	NA	0.85***	0.93***	0.21*				-0.21*	-0.27**	-0.19*		-0.19*	-0.22*	-0.17*		-0.17*
		-	NA	0.78***	0.87***						-0.54**					-0.38*		-0.48**
	Asthma/T2DM	+	NA	0.81***	0.98***						-0.66**
		-	NA	0.85***	0.91***	0.26**				-0.22**	-0.27***	-0.20*		-0.22**	-0.21*	-0.21*	-0.18*	-0.20*
	Asthma/hypertension	+	NA	0.79***	0.86***										-0.29*
		-	NA	0.86***	0.94***	0.24*		-0.26*		-0.26**	-0.37***	-0.31***		-0.30***	-0.19*	-0.21*		-0.30***
	Asthma/T2DM/hypertension	+	NA	0.85***	0.98***			-0.68*	-0.93**		-0.89***			0.69*
		-	NA	0.85***	0.93***	0.27**		-0.25*		-0.25**	-0.35***	-0.30**		-0.28**	-0.19*	-0.21*		-0.31**
	Asthma/allergic rhinitis	+	NA	0.85***	0.93***					-0.20*	-0.26**	-0.21*		-0.19*	-0.21*	-0.21*		-0.22*
		-	NA	0.80***	0.89***			-0.53**		-0.33*	-0.44**

NA, not applicable

^a ++, severe/very severe; +, mild/moderate

^*P < 0.05; ^**P < 0.01; ^***P < 0.001