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. 2024 Mar 23;14:38. doi: 10.1186/s13578-024-01206-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Bacterial-mediated RNAi of c-Myc extends survival of Apc^ΔISC mice. (A) Kaplan-Meier survival curves for 15-day Apc^ΔISC cohorts administered PBS (N = 14, red), 1 × 10⁶ CFU SL7207/SCR (N = 12, blue), or 1 × 10⁶ CFU SL7207/c-Myc (N = 12, green) (Mantel-Cox log rank test (PBS vs. c-Mycp = 0.003**, PBS vs. scrambled p = 0.197, scrambled vs. c-Mycp = 0.319). (B) Survival endpoint quantification of crypts from survival analysis staining positive for nuclear β-catenin. (C) Survival endpoint PCR analysis of small intestine from survival analysis mice demonstrating general absence of bacteria (survival days indicated). (D) PCR DNA analysis of Apc^ΔISC intestine 7 days following bacterial administration indicating variation in bacterial persistence. (E) c-Myc expression analysis of Apc^ΔISC intestine 7 days after bacterial administration. (F) Average number of nuclear β-catenin cells Apc^ΔISC crypts (N = 25) 7 days post bacteria administration (two-tailed Mann Whitney U- test, *p < 0.05, ***P < 0.001)