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. 2024 Mar 21;12:e17110. doi: 10.7717/peerj.17110

Table 2. Histopathological examination and inflammatory markers of groups (mean ± SD).

Groups (n:6)
Sample Control CMC Lecithin CMC+Inulin Lecithin+Inulin P value
Histopathology scores Ileum 0.0 ±0.0a 1.0 ±0.25b 1.0 ±0.25b 0.5 ±0.22a 0.7 ±0.21b <0.01**
Colon 0.2 ±0.16a 1.3 ±0.21b 1.7 ±0.21b 0.5 ±0.22ac 0.8 ±0.16c <0.001***
Villus length (µm) Ileum 399.8 ±9.58a 265.7 ±10.36b 250.3 ±7.64b 291.0 ±6.25c 298.8 ±4.79c <0.001***
Colon 103.0 ±4.65a 83.3 ±1.11b 77.8 ±3.12b 90.3 ±0.91c 87.0 ±6.16c <0.001***
Villus thickness (µm) Ileum 43.5 ±2.20a 56.2 ±1.07b 57.5 ±1.17b 43.3 ±0.66a 41.7 ±1.25a <0.001***
Colon 48.7 ±1.72a 54.3 ±0.55c 53.3 ±1.74bc 49.2 ±0.70a 50.0 ±0.70ab <0.001***
Crypt lenght (µm) Ileum 67.3 ±2.94a 42.8 ±3.06b 30.7 ±2.58c 52.7 ±2.80d 57.8 ±1.47e <0.001***
Colon 27.8 ±5.49a 15.3 ±2.50bc 11.7 ±1.86b 17.0 ±2.09c 16.8 ±1.94c <0.001***
Goblet cell count Ileum 55.8 ±2.24a 40.5 ±0.88b 42.3 ±1.14b 54.5 ±0.56a 51.0 ±2.38a <0.001***
Colon 108.8 ±2.35a 89.0 ±0.63b 92.5 ±1.47b 102.5 ±1.23c 103.5 ±1.66c <0.001***
Lcn-2 Stool 4.7 ±3.49 9.7 ±3.29 5.7 ±3.77 4.1 ±2.98 6.2 ±3.54 0.077
IL-6 Serum 105.8 ±8.41 96.3 ±11.73 101.5 ±10.10 111.6 ±2.98 102.3 ±7.42 0.063
IL-10 Serum 261.2 ±40.52a 179.5 ±29.47b 186.1 ±25.1b 238.6 ±40.52a 220.8 ±32.58a 0.001**

Notes.

a, b, c, d

There are statistical differences between the means having the different superscripts on the same line.

**

p < 0.05.

***

p < 0.001.