Table 2. Histopathological examination and inflammatory markers of groups (mean ± SD).
Groups (n:6) | |||||||
---|---|---|---|---|---|---|---|
Sample | Control | CMC | Lecithin | CMC+Inulin | Lecithin+Inulin | P value | |
Histopathology scores | Ileum | 0.0 ±0.0a | 1.0 ±0.25b | 1.0 ±0.25b | 0.5 ±0.22a | 0.7 ±0.21b | <0.01** |
Colon | 0.2 ±0.16a | 1.3 ±0.21b | 1.7 ±0.21b | 0.5 ±0.22ac | 0.8 ±0.16c | <0.001*** | |
Villus length (µm) | Ileum | 399.8 ±9.58a | 265.7 ±10.36b | 250.3 ±7.64b | 291.0 ±6.25c | 298.8 ±4.79c | <0.001*** |
Colon | 103.0 ±4.65a | 83.3 ±1.11b | 77.8 ±3.12b | 90.3 ±0.91c | 87.0 ±6.16c | <0.001*** | |
Villus thickness (µm) | Ileum | 43.5 ±2.20a | 56.2 ±1.07b | 57.5 ±1.17b | 43.3 ±0.66a | 41.7 ±1.25a | <0.001*** |
Colon | 48.7 ±1.72a | 54.3 ±0.55c | 53.3 ±1.74bc | 49.2 ±0.70a | 50.0 ±0.70ab | <0.001*** | |
Crypt lenght (µm) | Ileum | 67.3 ±2.94a | 42.8 ±3.06b | 30.7 ±2.58c | 52.7 ±2.80d | 57.8 ±1.47e | <0.001*** |
Colon | 27.8 ±5.49a | 15.3 ±2.50bc | 11.7 ±1.86b | 17.0 ±2.09c | 16.8 ±1.94c | <0.001*** | |
Goblet cell count | Ileum | 55.8 ±2.24a | 40.5 ±0.88b | 42.3 ±1.14b | 54.5 ±0.56a | 51.0 ±2.38a | <0.001*** |
Colon | 108.8 ±2.35a | 89.0 ±0.63b | 92.5 ±1.47b | 102.5 ±1.23c | 103.5 ±1.66c | <0.001*** | |
Lcn-2 | Stool | 4.7 ±3.49 | 9.7 ±3.29 | 5.7 ±3.77 | 4.1 ±2.98 | 6.2 ±3.54 | 0.077 |
IL-6 | Serum | 105.8 ±8.41 | 96.3 ±11.73 | 101.5 ±10.10 | 111.6 ±2.98 | 102.3 ±7.42 | 0.063 |
IL-10 | Serum | 261.2 ±40.52a | 179.5 ±29.47b | 186.1 ±25.1b | 238.6 ±40.52a | 220.8 ±32.58a | 0.001** |
Notes.
There are statistical differences between the means having the different superscripts on the same line.
p < 0.05.
p < 0.001.