Table 1.

Characteristics of the cohort

Patient Characteristics	Total 30,264	Female 13,493	Male 16,771
Neighbourhood income quintile, mean (SD)a,d	3 (1.42)	2.99 (1.41)*	3.17 (1.42)*
Age at index date, mean (SD)	72.17 (10.96)	75.06 (9.77)*	69.86 (11.32)*
CHA2DS2-VASc score, median (IQR)a,b	3 (1)	3 (2)*	3 (2)*
HAS-BLED, median (IQR)a,b	2 (1)	2 (1)*	2 (1)*
Weighted Charlson Comorbidity Index, median (IQR)a,c	5 (5)	5 (5)	5 (5)*
Number of concomitant medications, median (IQR)e	2 (3)	3 (4)*	2 (4)*
Number of OAC prescription refills over follow-up, median (IQR)	31 (43)	35 (50)*	29 (39)*

*Level of significance for Females vs. Males < 0.001 using unpaired T-test or Wilcoxon rank sum test with continuity correction

SD standard deviation; IQR interquartile range

^aMeasured during the baseline period

^bComorbidities were considered present if at least one disease-specific ICD code was present in either outpatient or inpatient records, during the baseline period. Maximum possible score is 9

^cScore range: 0–31. Zero indicates no comorbidities were found

^dThe average equivalized disposable income by postal code in patients’ residential area at index date, with 1 as the lowest and 5 as the highest level

^eNumber of medications used continuously (with no gap) for at least three months in the 6-months prior to index date