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. 2024 Mar 11;15:1355764. doi: 10.3389/fimmu.2024.1355764

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Copyright © 2024 Mandelli, Magri, Tortoli, Torricelli, Laera, Bagnoli, Finco, Bensi, Brazzoli and Chiarot

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between cellular localization and functionality of recognized antigens. Graph summarizing cellular localization and pathogenic activity of the S. aureus virulence factors recognized by sera from SpA_mut/AS01 immunized and S. aureus-infected mice. The 23 antigens recognized with higher frequency by sera from immunized and infected animals were further characterized by literature check and using the gene annotation present in NCBI data bank for their cellular localization (X axis) and in vivo/in vitro functionality (Y axis). Single dots reported information for single antigens as described in the legend. CSA family: conserved staphylococcal antigen family (32).