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. 2024 Mar 22;11(1):e002116. doi: 10.1136/bmjresp-2023-002116

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Post hoc Bayesian analysis^a of the phase 3 INCREASE trial: prior and posterior distributions for time to first disease progression. Distributions for PVR four (A) and PVR five (B). ^aPink solid distributions represent the posterior distributions of log HR, and the blue dashed lines represent the prior distributions. For optimistic, neutral and pessimistic prior distribution of log HR, normal distributions were used with the following parameters: optimistic (mean (SD)): 0.4 (0.2); neutral (mean (SD)): 0 (0.4); pessimistic (mean (SD)): 0.262 (0.2). For non-informative prior, uniform distribution was used. PVR, pulmonary vascular resistance.