Table 3.
incidence and grade of toxicities by dose level
| Total # of episodes by grade | ||||||
| Dose level | Term | # patients experiencing | 1 | 2 | 3 | 4 |
| Level 1 | Nausea | 3 | 6 | 1 | ||
| (n=3) | Diarrhea | 2 | 2 | |||
| Chills | 1 | 1 | 6 | |||
| Fatigue | 2 | 2 | ||||
| Headache | 2 | 4 | 4 | 3 | ||
| Fever | 1 | 2 | 3 | |||
| Hypotension | 1 | 1 | ||||
| Insomnia | 1 | 1 | ||||
| Anorexia | 2 | 1 | 1 | 1 | ||
| Pain | 2 | 1 | 1 | 1 | ||
| Totals | 15 | 17 | 10 | |||
| Level 2 | ||||||
| (n=3) | Nausea | 3 | 3 | 4 | 2 | |
| Anorexia | 3 | 6 | 3 | 3 | ||
| Fever | 3 | 1 | 6 | 4 | ||
| Emesis | 1 | 1 | ||||
| Chills | 2 | 3 | 4 | |||
| Headache | 3 | 2 | 2 | 9 | ||
| Pain | 3 | 6 | ||||
| Hypotension | 1 | 1 | ||||
| Fatigue | 3 | 3 | 2 | 6 | ||
| Infection, tumor site | 1 | 1 | ||||
| Totals | 8 | 27 | 19 | |||
| Level 3 | ||||||
| (n=3) | Nausea | 2 | 1 | 1 | ||
| Anorexia | 0 | |||||
| Fever | 2 | 6 | 2 | |||
| Emesis | 2 | 3 | ||||
| Chills | 0 | |||||
| Headache | 2 | 3 | 2 | |||
| Pain | 1 | 2 | ||||
| Hypotension | 1 | 3 | 5 | |||
| Fatigue | 0 | |||||
| Anemia | 1 | 1 | ||||
| Sore throat | 1 | 1 | ||||
| Sinus Tachycardia | 1 | 3 | ||||
| Totals | 19 | 13 | 1 | |||
| Phase II | ||||||
| (n=10) | Nausea | 3 | 2 | 3 | ||
| Anorexia | 0 | |||||
| Fever | 4 | 10 | 4 | |||
| Emesis | 3 | 3 | 5 | |||
| Chills | 3 | 2 | 12 | |||
| Headache | 6 | 7 | 7 | |||
| Pain | 1 | 2 | ||||
| Hypotension | 1 | 3 | 5 | |||
| Fatigue | 1 | 1 | ||||
| Blurred vision | 1 | 1 | ||||
| Hypoxia | 1 | 1 | ||||
| Sore throat | 1 | 1 | ||||
| Total | 19 | 13 | 1 | |||