Table 1.
Characteristics of individuals with weak D types 1, 2, 3, 4.0, 4.1, and Asian-type DEL and guidance for Rho(D) immune globulin administration
| RhD type | Designation | ISBT nomenclature |
Molecular variant(s) |
Prevalent ethnicity | Serologic testing | Transfusion recommendation | Rh immunoprophylaxis in pregnancy | ||
|---|---|---|---|---|---|---|---|---|---|
| Anti-D reagent |
Weak D test |
Adsorption/ elution test |
|||||||
| Weak D types 1, 2, 3, 4.0, 4.1 | Weak D type 1 |
RHD*01W.1
RHD*weak D type 1 |
c.809T>G | European Americans | Negative | Positive | Positive | D-positive blood units are possible | Unnecessary |
| Weak D type 2 |
RHD*01W.2
RHD*weak D type 2 |
c.1154G>C | European Americans | Negative | Positive | Positive | D-positive blood units are possible | Unnecessary | |
| Weak D type 3 |
RHD*01W.3
RHD*weak D type 3 |
c.8C>G | European Americans | Negative | Positive | Positive | D-positive blood units are possible | Unnecessary | |
| Weak D type 4.0 |
RHD*09.03
RHD*DAR3 |
c.602C>G c.667T>G |
African Americans | Negative | Positive | Positive | D-positive blood units are possible | Unnecessary | |
| Weak D type 4.1 |
RHD*09.04
RHD*DAR4 |
c.602C>G c.667T>G c.819G>A |
African Americans | Negative | Positive | Positive | D-positive blood units are possible | Unnecessary | |
| Asian-type DEL | RHD (1227G>A) |
RHD*01EL.01
RHD*DEL1 |
c.1227G>A | East Asians | Negative | Negative | Positive | D-positive blood units are possible | Unnecessary |
Abbreviation: ISBT, International Society of Blood Transfusion.