Table 1.

Optimization for Enantioselective Aminocynation

entry	deviations from above conditions	yield (%)a	ee (%)b
1	none	35	80
2	L1 instead of sBOX(iPr)	23	72
3	L2 instead of sBOX(iPr)	10	33
4	L3 instead of sBOX(iPr)	31	52
5	DCE instead of MeCN	24	71
6	EtOAc instead of MeCN	49	69
7	Cu(MeCN)4BF4 instead of Cu(OTf)2	20	74
8	0.05 M	30	75
9	45 °C	16	75
10	No Cu(OTf)2 or no Mes-Acr-BF4 or no light	<5	–

^aReactions were run at 0.2 mmol scale with 2 mL of solvent.

^bee was determined by HPLC with chiral stationary phase.