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. 2024 Mar 25;43:90. doi: 10.1186/s13046-024-03016-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Higher GGT1 correlates to shorter overall survival of breast cancer patients. A mRNA level of GGT1 in 1113 breast cancer tissues and 113 benign normal tissues from TCGA database. B IHC analysis of GGT1 expression in breast cancer (Tumor) and peritumor tissues (Normal) from our cohort (n = 70), (scale bar = 100 μm). C Protein level of GGT1 in 4 breast cancer tissues and their adjacent normal tissues was determined by western blot. D Protein level of GGT1 in six breast cancer cell lines (MCF-7, MDA-MB-231, SKBR-3, T47D, BT-549 and SUM149) and a non-transformed mammary epithelial cell line (HMEC-hTERT) was determined by western blot. E Protein level of GGT1 in mammosphere derived from MCF-7 and MDA-MB-231 cells and their parental cells was evaluated by western blot. F Kaplan–Meier analysis of the relationship between GGT1 expression levels and overall survival of breast cancer patients from TCGA database. *p < 0.05; **p < 0.01; ***p < 0.001 (log-rank test in F, others unpaired two-tailed Student’s t test)