Table 1. Relationship between PPARs family member expression and clinicopathological features in the TCGA-STAD cohort.
| PPARA | PPARD | PPARG | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | High, N = 1871 | Low, N = 1881 | p-value 2 | High, N = 1871 | Low, N = 1881 | p-value 2 | High, N = 1871 | Low, N = 1881 | p-value 2 |
| T.Stage | 0.90 | 0.80 | 0.30 | ||||||
| T1+T2 | 48 (27%) | 51 (27%) | 51 (28%) | 48 (26%) | 53 (29%) | 46 (25%) | |||
| T3+T4 | 132 (73%) | 136 (73%) | 134 (72%) | 134 (74%) | 127 (71%) | 141 (75%) | |||
| Unknown | 7 | 1 | 2 | 6 | 7 | 1 | |||
| N.Stage | 0.88 | 0.84 | 0.76 | ||||||
| N0 | 56 (31%) | 55 (31%) | 56 (31%) | 55 (32%) | 54 (30%) | 57 (32%) | |||
| NX | 122 (69%) | 124 (69%) | 127 (69%) | 119 (68%) | 124 (70%) | 122 (68%) | |||
| Unknown | 9 | 9 | 4 | 14 | 9 | 9 | |||
| M.Stage | 0.56 | 0.16 | 0.56 | ||||||
| M0 | 165 (94%) | 165 (92%) | 163 (91%) | 167 (95%) | 165 (92%) | 165 (94%) | |||
| M1 | 11 (6.2%) | 14 (7.8%) | 16 (8.9%) | 9 (5.1%) | 14 (7.8%) | 11 (6.2%) | |||
| Unknown | 11 | 9 | 8 | 12 | 8 | 12 | |||
| Stage | 0.33 | 0.77 | 0.35 | ||||||
| I+II | 77 (44%) | 87 (49%) | 82 (46%) | 82 (47%) | 85 (49%) | 79 (44%) | |||
| III+IV | 98 (56%) | 90 (51%) | 97 (54%) | 91 (53%) | 88 (51%) | 100 (56%) | |||
| Unknown | 12 | 11 | 8 | 15 | 14 | 9 | |||
| Grade | 0.36 | 0.12 | 0.006 | ||||||
| G1+G2 | 77 (43%) | 70 (38%) | 80 (44%) | 67 (36%) | 86 (47%) | 61 (33%) | |||
| G3+G4 | 104 (57%) | 115 (62%) | 101 (56%) | 118 (64%) | 96 (53%) | 123 (67%) | |||
| Unknown | 6 | 3 | 6 | 3 | 5 | 4 | |||
| Age | 0.046 | 0.21 | 0.005 | ||||||
| <=60 | 51 (28%) | 70 (37%) | 54 (30%) | 67 (36%) | 47 (26%) | 74 (39%) | |||
| >60 | 133 (72%) | 117 (63%) | 129 (70%) | 121 (64%) | 136 (74%) | 114 (61%) | |||
| Unknown | 3 | 1 | 4 | 0 | 4 | 0 | |||
| Gender | 0.80 | 0.006 | 0.37 | ||||||
| FEMALE | 68 (36%) | 66 (35%) | 54 (29%) | 80 (43%) | 71 (38%) | 63 (34%) | |||
| MALE | 119 (64%) | 122 (65%) | 133 (71%) | 108 (57%) | 116 (62%) | 125 (66%) | |||
Notes.
1
Median (IQR) or Frequency (%).
2
Pearson’s Chi-squared test.