Table 4.
Brain imaging abnormalities analyzed by initial diagnosis category.
| Variables, n (%) | ALSP (n = 72) |
Frontotemporal dementia (n = 27)a |
Multiple sclerosis (n = 21) |
Cerebrovascular disease (n = 9) |
Familial leukoencephalopathy (n = 8) |
Alzheimer’s disease (n = 7) |
Adult-onset leukodystrophy (n = 5) |
Nonspecific neurodegeneration or dementia (n = 43) |
Other (n = 20)a |
Missing (n = 67)a |
p value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| White matter hyperintensities | 66 (91.7) | 14 (51.9) | 17 (81.0) | 5 (55.6) | 0 | 3 (42.9) | 5 (100) | 25 (58.1) | 13 (65.0) | 54 (80.6) | <0.001 |
| Corpus callosum irregularitiesb | 32 (44.4) | 5 (18.5) | 8 (38.1) | 3 (33.3) | 0 | 2 (28.6) | 2 (40.0) | 6 (14.0) | 2 (10.0) | 36 (53.7) | 0.053 |
| Atrophy | 27 (37.5) | 10 (37.0) | 7 (33.3) | 3 (33.3) | 0 | 2 (28.6) | 3 (60.0) | 12 (27.9) | 4 (20.0) | 26 (38.8) | 0.516 |
| White matter calcification | 28 (38.9) | 1 (3.7) | 3 (14.3) | 4 (44.4) | 0 | 0 | 0 | 5 (11.6) | 2 (10.0) | 3 (4.5) | <0.001 |
| Ventricular enlargement | 20 (27.8) | 3 (11.1) | 1 (4.8) | 1 (11.1) | 0 | 2 (28.6) | 0 | 3 (7.0) | 2 (10.0) | 8 (11.9) | <0.001 |
ALSP, adult-onset leukoencephalopathy with axonal spheroids and pigmented glia.
a
Cases with missing age (n = 12) were not included in the analysis of variance.
b
Thinning and/or hyperintensities.